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Future of Health Care and Biotech / Future of Ageing, human cloning, stem cells, oncolytic viruses, - video 3 by Patrick Dixon for Leica Microsystems

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This is the third video in a series by Patrick Dixon on the future of Health Care, made by Patrick Dixon for Leica Microsystems.  Here is a summary of content - numbers in brackets are number of minutes per item (approximate).

VIDEO 3. How biotech will alter life itself

From immunology to genetics to epigenetics (environment)

Viruses to cure disease – oncolytic story (10)
    How oncolytic viruses work
    Combination with chemo
    Viruses to deliver new genes for chemo / radiotherapy
    Ability to cut and past genes or write new ones
    Virus to alter hair colour
Virus to cure deafness

Cloning, stem cells and how to re-engineer the human body  (10)
    Myths and realities of stem cells (3)
    Progress in heart, brain, liver etc
    Grow new teeth
    Heart and brain repair
    Woman with male brain
    New bladder, trachea, kidney, liver - scaffolding
    Printing new organs (3D)
    Printing new skin

Can we stop ageing? (15)
Monkeys and mice on diets / metformin (4)
7 mechanisms of ageing in every living cell
    cell loss or atrophy without replacement
        regenerating thymus (2)
    oncogenic nuclear mutations and epimutations
    mitochondrial mutations
    cell senescence (death resistant cells)
        activating telomerase (2)
    intra-cellular junk
    extra-cellular junk
    random extra-cellular cross-linking (3)
        Alteon story
Non-ageing whales and rockfish  (3)

What kind of world do we want to live in?
Danger of growing gap between wealthy and poorest
Contrast greatest in emerging markets  (2)

Test of all great life sciences research: potential to radically improve human life. (2)

Power of science to transform life on earth if we all work together, collaborating, innovating, with new kinds of partnerships, making and sharing important discoveries for the good of all humankind.   (3)

You may wish to watch the other two videos.... see links below

Need a world-class medtech speaker for your event? Phone or e-mail Patrick Dixon now.

VIDEO 1. Future of Health Care and Life Sciences - watch now

Big global trends which affect even the smallest research project (3)
How rapid events are overtaking research strategies
What next in the global economic crisis and why it matters for future funding of medical research

Why future of life sciences will be driven by emotion – and importance of telling the story to gain funding in future – see Video 2 (2)

Demographics (6)
    1 billion children will be adults in 18 years
    1 billion new emerging middle class
    New models for mass-market health care
    1 billion adults will be over 65 in 10 years
    Europe dying
    65% health spending on over 65s
    66% of over 50s will be in Asia in 2050
    Most over 65 have multiple chronic conditions

Major health challenges in next 20 years: (5)

    Neurodegenerative NB Alzheimers
    Cancer / obesity + DIABETES / chronic wounds
    Infections / joints wearing out
    Care of elderly at home etc
    Growing cost of health care
    Ethical issues in rationing / choices about treatment types

Major health advances eg (13)
    Endoscopy - $75bn market by 2022 – and stents etc
    Ability to detect live cancer cells in operations (Dune)
    Cancer therapy
    Heart disease and stroke management
    Better understanding of lifestyle / nutrition / neutraceuticals
Eg Alzheimers and mitochondria boost (both see again under ageing in video 3)
    Computer-aided diagnosis
    Digitised patient records
    Huge expansion community care
    Telemonitoring and home testing
    Virtual medicine
    Web tools for patients – know more than their doctors
    Social media – sharing experience / scoring carers

Shift from treating sick, to prevention, to performance (2)
    ? Can we stop ageing ? – answer in video 3
Future huge unmet needs – to drive research: (2)
    Alzheimers / neurodegeneration
    All aspects of ageing

Where will future funding come from in age of austerity? (5)
Stress on governments, universities, pharma, Venture Capital, Foundations etc
Why pharma is in trouble – pipeline length, patent expiry, generics, lack of innovation
Importance of Patrons – wealthy individuals
Importance of telling the story – including social media
Future of publications – who owns your results?
New models for research – collaboration, co-opetition, partnership
Crowd-sourcing, crowd-funding, open-innovation – what it means for research

VIDEO 2. How medical technology (medtech) will change the world - watch now

Astonishing advances we will see in next decade deiven by med tech. (3)

Convergence: biotech, nanotech, digital, physics, chemistry (16)
Ability to read your genome in 2 hours (4)
Fusion of fluidics, physics, immunology etc
Falling cost per genome
Biodigital brains and thought control (2)
Role of Big Data and cloud processing – combine medical records, lifestyle info, gene profiles, pharmacogenomics (3)
Genes for speech, memory, murder, shyness and happiness (2)
Genetic prophecy and ethical issues for insurers (2)
    And the ultimate nano-tech robot is…..(3)

Clinical impact on laboratory research and innovation (2)
Why biggest budgets for research and development are for clinical med tech, and how these innovations will drive progress in the lab

Future of next-generation imaging – examples from clinical research. (4)

Next generation microscopy (10)
    Watching activities inside living cells
    Structural, chemical and electrical signals
Visualisng cellular, sub-cellular and molecular components
Visualisation of single molecules within a cell
    Ultra-high resolution techniques
Ways to beat limits of >200nm light wavelength
Nanoscopy with focused light
Confocal Super-Resolution Microscopy / STED Microscopy
Widefield Super-Resolution Microscopy / Localization Microscopy - 3D analysis, measurement
Impact on future life sciences research

New ways to restore sight or hearing – devices (2)

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